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CYCLOPENTANEMETHANAMINE, 1-(4-MORPHOLINYL)- synthesis

1synthesis methods
-

Yield:444666-61-9 90.2%

Steps:

23.1 Step 1:

Step 1:
Synthesis of (1-morpholinocyclopentyl)methanamine
Cyclopentanone (3.000 mL, 33.880 mmol) and morpholine (3.810 mL, 44.044 mmol) as starting materials were used in a similar manner to Step 2 of Example 1 to obtain 1-morpholinocyclopentane-1-carbonitrile (5.510 g, 90.2%) as white solid, followed by obtaining (1-morpholinocyclopentyl)methanamine (5.500 g, 97.6%, light yellow liquid): LRMS (ES) m/z 185.09 [M+H]+, calculated MW 184.28.

References:

US2022/274939,2022,A1

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