Cyclopentanesulfonamide (9CI) synthesis
- Product Name:Cyclopentanesulfonamide (9CI)
- CAS Number:73945-39-8
- Molecular formula:C5H11NO2S
- Molecular Weight:149.21
26394-17-2
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Yield:73945-39-8 100%
Reaction Conditions:
with ammonium hydroxide;water at 20;
Steps:
Intermediate I11: cyclopentanesulfonamide
Cyclopentanesulfonyl chloride (675 mg, 619 μL, 4 mmol, Eq: 1.0) was added dropwise at rt to ammonium hydroxide solution (30-33% in water, 10.8 g, 12 mL, 92.5 mmol, Eq: 23.1). The reaction mixture was stirred overnight at rt. After 20.5 h, HCl (25% aq.) was added dropwise until the pH of the solution was 7. The reaction mixture was extracted 3 × with EtOAc, the combined organic layers were washed 1 × with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was dried under high vacuum to give the title compound as a light brown solid (658 mg, 91% purity, 100% yield). 1H NMR (300 MHz, DMSO-d6) δ ppm 1.42 - 1.74 (m, 4 H) 1.76 - 1.95 (m, 4 H) 3.33 - 3.45 (m, 1 H) 6.69 (s, 2 H).
References:
WO2021/116050,2021,A1 Location in patent:Page/Page column 42
32916-51-1
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32916-51-1
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7051-34-5
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