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CYCLOPENTYL-THIOPHEN-2-YLMETHYL-AMINE synthesis

1synthesis methods
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Yield:58924-50-8 63%

Reaction Conditions:

Stage #1: thiophene-2-carbaldehyde;Cyclopentamine in dichloromethane;Molecular sieve;
Stage #2: with sodium tris(acetoxy)borohydride in dichloromethane;Molecular sieve;

References:

Giroud, Maude;Ivkovic, Jakov;Martignoni, Mara;Fleuti, Marianne;Trapp, Nils;Haap, Wolfgang;Kuglstatter, Andreas;Benz, J?rg;Kuhn, Bernd;Schirmeister, Tanja;Diederich, Fran?ois [ChemMedChem,2017,vol. 12,# 3,p. 257 - 270] Location in patent:supporting information