D-2-Thiolhistidine synthesis
- Product Name:D-2-Thiolhistidine
- CAS Number:1195264-93-7
- Molecular formula:C6H9N3O2S
- Molecular Weight:187.22
328526-86-9
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Yield:1195264-93-7 51%
Reaction Conditions:
Stage #1: (R)-histidine monohydrochloride monohydratewith bromine in water at -2 - 0; for 0.0833333 - 0.116667 h;
Stage #2: with L-Cysteine in water at 0; for 1 h;
Stage #3: with 3-mercaptopropionic acid at 95; for 18 h;
References:
Erdelmeier, Irene;Daunay, Sylvain;Lebel, Remi;Farescour, Laurence;Yadan, Jean-Claude [Green Chemistry,2012,vol. 14,# 8,p. 2256 - 2265] Location in patent:experimental part