ChemicalBook CAS DataBase List D(-)-AC-ALPHA-PHENYLGLYCINOL

D(-)-AC-ALPHA-PHENYLGLYCINOL synthesis

8synthesis methods

Product Name:D(-)-AC-ALPHA-PHENYLGLYCINOL
CAS Number:78761-26-9
Molecular formula:C10H13NO2
Molecular Weight:179.22

56613-80-0
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$5.00/1g

141-78-6 Synthesis

141-78-6
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$24.69/250ml

78761-26-9
30 suppliers
$65.00/500mg

Yield:78761-26-9 91%

Reaction Conditions:

with Trimethylacetic acid at 90; for 24 h;Inert atmosphere;chemoselective reaction;

Steps:

Typical procedure for N-acetylation of primary aliphatic amines (Table 1, entry 9):

General procedure: To a solution of ^tBuCO₂H (3d) (30.9 mg, 0.30 mmol) in EtOAc (3.0 mL) at room rtemperature was added 3-amino-1-phenylbutane (1) (48.7 μL, 0.30 mmol). The reaction mixture was refluxed (90 °C) for 24 h and then it was evaporated the solvent. The crude product was purified preparative thin layer chromatography on silica (hexane/EtOAc/35% NH₃ = 25/75/1) to afford the corresponding acetoamide 2 (57.0 mg, 99% yield) as a colorless oil.

References:

Yoshida, Tomoki;Kawamura, Shimpei;Nakata, Kenya [Tetrahedron Letters,2017,vol. 58,# 12,p. 1181 - 1184] Location in patent:supporting information