D-Norleucine, 2-(aminomethyl)- (9CI) synthesis

1synthesis methods

Product Name:D-Norleucine, 2-(aminomethyl)- (9CI)
CAS Number:160557-06-2
Molecular formula:C7H16N2O2
Molecular Weight:160.21

327-56-0 Synthesis

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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 95 percent / 1 M aq. NaOH / ethanol
2: 56 percent / CH₂Cl₂ / -20 °C
3: 1.) LiN(SiMe₃)2 / 1.) THF, from -78 to -65 deg C, 2.) THF
4: 86 percent / 40percent w/v aq. HBr / 3 h / Heating

References:

Jones, Raymond C. F.;Crockett, Alan K.;Rees, David C.;Gilbert, Ian H. [Tetrahedron Asymmetry,1994,vol. 5,# 9,p. 1661 - 1664]