D-PENCILLAMINE METHYL ESTER HYDROCHLORIDE synthesis
- Product Name:D-PENCILLAMINE METHYL ESTER HYDROCHLORIDE
- CAS Number:34297-27-3
- Molecular formula:C6H14ClNO2S
- Molecular Weight:199.7
Yield:34297-27-3 98%
Reaction Conditions:
with hydrogenchloride at 20;
Steps:
Synthetic protocols
d-Penicillamine methyl ester hydrochloride (2) was synthesized by dissolving 0.10 g (0.67 mmol) d-penicillamine (1) in 5 ml methanol and bubbling dry HCl gas into the solution for 15 min at room temperature
[19]
.
After stirring overnight at room temperature the reaction mixture was evaporated in vacuo to yield a white solid (0.13 g, 98%). Mp: 187-188 °C; 1H NMR (600 MHz, H2O:D2O, 95:5, v/v) δ (ppm) 1.42 (3H, s, βCH3), 1.45 (3H, s, βCH3), 3.68 (1H, s, αH), 3.79 (3H, s, OCH3); HRMS m/z [M+H]+ Calc 164.0745 Found 164.0724.
References:
Mirzahosseini, Arash;Szilvay, András;Noszál, Béla [Chemical Physics Letters,2014,vol. 610-611,p. 62 - 69]
