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ChemicalBook CAS DataBase List Deacetyl Racecadotril

Deacetyl Racecadotril synthesis

2synthesis methods
141437-87-8 Synthesis
Racecadotril Diacid Impurity

141437-87-8
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: 87 percent / Et3N, 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran; CHCl3 / Ambient temperature
2: 97 percent / Zn, 1 M aq. HCl / methanol / 2 h / Ambient temperature

References:

Fournie-Zaluski, Marie-Claude;Coric, Pascal;Turcaud, Serge;Lucas, Evelyne;Noble, Florence;et al. [Journal of Medicinal Chemistry,1992,vol. 35,# 13,p. 2473 - 2481]