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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 7H-Pyrrolo[2,3-d]pyrimidine

7H-Pyrrolo[2,3-d]pyrimidine synthesis

8synthesis methods
3680-69-1 Synthesis
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

3680-69-1
802 suppliers
$6.00/1g

7H-Pyrrolo[2,3-d]pyrimidine

271-70-5
189 suppliers
$8.00/100mg

-

Yield:271-70-5 98%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol under 760.051 Torr; for 16 h;

Steps:

1a; 1.i
As shown in Figure 1-step i, 4-chloro-7H-pyrrolo[2,3-d]pyrimidine(compound 1001) (130 mg, 0.847 mmol) was dissolved in 3 mL of methanol and hydrogenated under 1 atm of hydrogen over Pd-C 10% for 16 hours. Concentration to dryness provided 100 mg (98%) of 7H-pyrrolo[2,3-d ]pyrimidine [compound 1002, 1H-NMR(CD3OD): δ 9.4 (s, IH); 9.1 (s, IH); 7.9 (s, IH); 7.1 (s, IH)].

References:

VERTEX PHARMACEUTICALS INCORPORATED WO2007/41130, 2007, A2 Location in patent:Page/Page column 40; Sheet 1/9

FullText

530-91-6 Synthesis
1,2,3,4-TETRAHYDRO-2-NAPHTHOL

530-91-6
88 suppliers
$15.00/100mg

3680-69-1 Synthesis
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

3680-69-1
802 suppliers
$6.00/1g

7H-Pyrrolo[2,3-d]pyrimidine

271-70-5
189 suppliers
$8.00/100mg

References
2-Naphthalenethiol, 1,2,3,4-tetrahydro-

57071-25-7
1 suppliers
inquiry

3680-69-1 Synthesis
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

3680-69-1
802 suppliers
$6.00/1g

7H-Pyrrolo[2,3-d]pyrimidine

271-70-5
189 suppliers
$8.00/100mg

References
4H-Pyrrolo[2,3-d]pyrimidine-4-thione,3,7-dihydro-

1421-27-8
1 suppliers
inquiry

7H-Pyrrolo[2,3-d]pyrimidine

271-70-5
189 suppliers
$8.00/100mg

References
3680-71-5 Synthesis
Pyrrolo[2,3-d]pyrimidin-4-ol

3680-71-5
399 suppliers
$6.00/1g

7H-Pyrrolo[2,3-d]pyrimidine

271-70-5
189 suppliers
$8.00/100mg

References

7H-Pyrrolo[2,3-d]pyrimidine Related Search:

Pyrrolo[2,3-d]pyrimidin-4-ol 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol 4-(Hydroxyamino)-4-oxobutanoic acid N-Hydroxysuccinimide Benzyl chloride Malonyl chloride N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine