desmethylmianserin synthesis
- Product Name:desmethylmianserin
- CAS Number:71936-92-0
- Molecular formula:C17H18N2
- Molecular Weight:250.34
![Benzaldehyde, 2-[(phenylmethyl)amino]-](/CAS/20210305/GIF/147611-22-1.gif)
147611-22-1
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71936-92-0
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Yield:-
Steps:
Multi-step reaction with 10 steps
1: methanol / 2 h / 60 °C
2: palladium diacetate; 1,4-di(diphenylphosphino)-butane; potassium carbonate / 1,4-dioxane / 100 °C / Inert atmosphere
3: ammonium formate; palladium 10% on activated carbon / methanol / 15 h / Reflux
4: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Reflux
5: manganese(IV) oxide / toluene / 24 h / 110 °C
6: potassium tert-butylate / water / 48 h / 25 °C
7: nickel dichloride; sodium tetrahydroborate; methanol / 1 h / 0 °C
8: dichloromethane / 2 h / 0 °C
9: sodium iodide; sodium hydrogencarbonate / acetone / 72 h / 70 °C
10: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux
References:
Huang, Xueliang;Ma, Liyao;Xia, Jiajin;Xin, Luoting;Yu, Yinghua;Zhu, Lei [Angewandte Chemie - International Edition,2020,vol. 59,# 41,p. 18261 - 18266][Angew. Chem.,2020,vol. 132,# 41,p. 18418 - 18423,6]
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119200-54-3
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71936-92-0
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![5,11-dihydrobenzo[c][2]benzazepin-6-one](/CAS2/GIF/1211-06-9.gif)
1211-06-9
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71936-92-0
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![11H-Dibenz[b,e]azepine](/CAS/GIF/256-86-0.gif)
256-86-0
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71936-92-0
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41218-84-2
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71936-92-0
26 suppliers
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