![](/CAS/GIF/64-85-7.gif)
Desoxycorticosterone synthesis
- Product Name:Desoxycorticosterone
- CAS Number:64-85-7
- Molecular formula:C21H30O3
- Molecular Weight:330.46
![Pregna-4,6-diene-3,20-dione, 21-hydroxy-](/CAS/GIF/17916-84-6.gif)
17916-84-6
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![Desoxycorticosterone](/CAS/GIF/64-85-7.gif)
64-85-7
125 suppliers
$15.00/5mg
Yield:64-85-7 91.9%
Reaction Conditions:
with formic acid in isopropyl alcohol at 76 - 80;Inert atmosphere;
Steps:
7 Selective reduction of 21-hydroxy-6-dehydroprogesterone to 21-hydroxyprogesterone
1] Add 328.5g of 21-hydroxy-6-dehydroprogesterone, 3500ml of isopropanol, 130.0g of Raney nickel, 140.0g of formic acid to a 5L reaction kettle, and protect with nitrogen, and heat to reflux (76-80 ° C) with stirring;2] Reaction at reflux (temperature 76 ~ 80 ° C) for 8 hours;3] When the reaction is completed, stop heating and filter off the catalyst while hot;4The filtrate is heated, and the solvent is distilled under normal pressure;5] Distill off 2950ml of solvent and add 1900ml of purified water;6] The temperature was lowered to 5-20 ° C, suction-filtered, washed twice with 900 ml of purified water, and dried to obtain 303.7 g of 21-hydroxyprogesterone crystals in a yield of 91.9%.
References:
Shanxi Han River Pharmaceutical Group Co., Ltd.;Zhang Jia;Chen Zhi;Hu Haijun CN104530166, 2016, B Location in patent:Paragraph 0082-0089
![Pregn-4-ene-3,20-dione, 21-bromo-](/CAS/20210305/GIF/26987-66-6.gif)
26987-66-6
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![Desoxycorticosterone](/CAS/GIF/64-85-7.gif)
64-85-7
125 suppliers
$15.00/5mg
![Progesterone](/CAS/GIF/57-83-0.gif)
57-83-0
794 suppliers
$15.00/1g
![Desoxycorticosterone](/CAS/GIF/64-85-7.gif)
64-85-7
125 suppliers
$15.00/5mg
![21-diazopregn-4-ene-3,20-dione](/CAS/GIF/53892-00-5.gif)
53892-00-5
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![Desoxycorticosterone](/CAS/GIF/64-85-7.gif)
64-85-7
125 suppliers
$15.00/5mg