Deterenol Hydrochloride synthesis

Yield:23239-36-3 91%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol at 20; under 760.051 Torr; for 24 h;

Steps:

13

2-Isopropylamino-1-(4-hydroxyphenyl)-ethanol hydrochloride was synthesized as follows: 1.0 g of 2-isopropyl amino-1-(4-hydroxyphenyl)-ethanone hydrochloride [formula shown in Example 4, above] was dissolved in 15ml methanol, 50 mg of 10% palladium on active carbon was added to the resulting solution. Hydrogen was introduced after the air in the reactor removed. The reaction mixture was stirred at room temperature for 24 hours under atmospheric pressure. Upon the completion of the reduction reaction, the catalyst was filtered, and the filtrate was concentrated to dryness. The residue was crystallized from methanol to obtain colorless crystals 0.91 g, yield 91%. mp 152-152.5 C.

References:

US2005/250944,2005,A1 Location in patent:Page/Page column 21