ChemicalBook CAS DataBase List DI-N-BUTYLMETHYLCHLOROSILANE

DI-N-BUTYLMETHYLCHLOROSILANE synthesis

6synthesis methods

Product Name:DI-N-BUTYLMETHYLCHLOROSILANE
CAS Number:996-07-6
Molecular formula:C9H21ClSi
Molecular Weight:192.8

106-98-9 Synthesis

106-98-9
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996-07-6
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Yield:996-07-6 99%

Reaction Conditions:

with heterogenous platinum-based catalyst Y₁EX₂ in tetrahydrofuran at -196 - 120; for 21 h;Sealed tube;

Steps:

b.3 Entry B12/Table 7: Target reaction: MeSiBuHCl + 1-butene → MeSiBu2Cl

The product mixture obtained from entry A10¹/Table 3 was transferred into an ampule that was equipped with an NMR tube to monitor product distribution in a closed system, containing 34 mg of the catalyst (Y1EX2) and 5 mL of dry THF. Subsequently, 2.32 g of but-1-ene were condensed onto the reaction mixture that was cooled to -196 °C. The ampule was evacuated, sealed in vacuo and placed in a drying cabinet for 21 h at 120 °C. MeSiBuHCl was fully converted into MeSiBu2Cl as identified by NMR spectroscopy and GC-MS analysis. After separation of all volatiles by condensation in vacuo, MeSiBu2Cl (1.78 g, 9.3 mmol, 99 % yield) was isolated still dissolved in 5 mL THF. The mixture was used without further purification. (MeSiBu₂Cl: δ²⁹Si = 31.5 ppm, R_T = 17.82 min).

References:

WO2021/243137,2021,A1 Location in patent:Page/Page column 65; 68; 69