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ChemicalBook CAS DataBase List Diethyl 2-(cyanomethyl)malonate

Diethyl 2-(cyanomethyl)malonate synthesis

5synthesis methods
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Yield:17109-93-2 87%

Reaction Conditions:

Stage #1: diethyl malonatewith sodium hydride in tetrahydrofuran at 0; for 0.5 h;
Stage #2: cyanomethyl bromide in tetrahydrofuran at 20; for 17 h;Further stages.;

References:

Bowman;Bridge;Brookes;Cloonan;Leach [Journal of the Chemical Society. Perkin Transactions 1 (2001),2002,vol. 2,# 1,p. 58 - 68]