![](/CAS/GIF/589-57-1.gif)
DIETHYL CHLOROPHOSPHITE synthesis
- Product Name:DIETHYL CHLOROPHOSPHITE
- CAS Number:589-57-1
- Molecular formula:C4H10ClO2P
- Molecular Weight:156.55
![ETHYL PHOSPHORODICHLORIDITE](/CAS/GIF/1498-42-6.gif)
1498-42-6
57 suppliers
$40.00/250mg
![Ethanol](/CAS/GIF/64-17-5.gif)
64-17-5
706 suppliers
$10.00/50g
![DIETHYL CHLOROPHOSPHITE](/CAS/GIF/589-57-1.gif)
589-57-1
158 suppliers
$37.29/5g
![Triethyl phosphite](/CAS/GIF/122-52-1.gif)
122-52-1
245 suppliers
$9.00/5g
Yield:589-57-1 82% ,122-52-1 18%
Reaction Conditions:
with triethylamine in toluene
Steps:
15 Example 15
Synthesis of phosphorochloridite 1e and phosphorodichloridite 2e. This example shows that aliphatic phosphorochloridites and phosphorodichloridites can be produced in good selectivity. [0044] A temperature controlled 300 ml baffled round bottom flask was charged with a solution of 25 ml 2.0 molar PCl3 in toluene. Under vigorous stirring a solution of 25 ml 2.0 molar triethylamine in toluene and a solution of 25 ml 2.0 molar ethylalcohol in toluene were added separately and concurrently via a dual syringe pump over a period of 100 min. During the addition period the reaction temperature was maintained at -10° C. The 31P NMR analysis exhibited transformation to the corresponding dichloridite 2e in 94% selectivity. Another 25 ml of each 2.0 molar triethylamine solution in toluene and 2.0 molar ethylalcohol solution in toluene were added separately and concurrently via dual syringe pump over a period of 100 min. The 31P NMR analysis exhibited transformation to the corresponding chloridite 1e in 70% overall selectivity. Another 4.7 ml of each 2.0 molar triethylamine solution in toluene and 2.0 molar ethylalcohol solution in toluene were added separately and concurrently via a dual syringe pump. The final product distribution was 82% phosphorochloridite 1e and 18% triethylphosphite. No Ethylchloride was formed.
References:
Ritter, Joachim C. US2004/106815, 2004, A1 Location in patent:Page 5-6
![Triethyl phosphite](/CAS/GIF/122-52-1.gif)
122-52-1
245 suppliers
$9.00/5g
![DIETHYL CHLOROPHOSPHITE](/CAS/GIF/589-57-1.gif)
589-57-1
158 suppliers
$37.29/5g
![Ethanol](/CAS/GIF/64-17-5.gif)
64-17-5
706 suppliers
$10.00/50g
![DIETHYL CHLOROPHOSPHITE](/CAS/GIF/589-57-1.gif)
589-57-1
158 suppliers
$37.29/5g
![Diethyl chlorothiophosphate](/CAS/GIF/2524-04-1.gif)
2524-04-1
7 suppliers
$16.80/25G
![DIETHYL CHLOROPHOSPHITE](/CAS/GIF/589-57-1.gif)
589-57-1
158 suppliers
$37.29/5g
![Ethanol](/CAS/GIF/64-17-5.gif)
64-17-5
706 suppliers
$10.00/50g
![DIETHYL CHLOROPHOSPHITE](/CAS/GIF/589-57-1.gif)
589-57-1
158 suppliers
$37.29/5g
![ETHYL PHOSPHORODICHLORIDITE](/CAS/GIF/1498-42-6.gif)
1498-42-6
57 suppliers
$40.00/250mg
![Triethyl phosphite](/CAS/GIF/122-52-1.gif)
122-52-1
245 suppliers
$9.00/5g