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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Difloxacin

Difloxacin synthesis

11synthesis methods
704-10-9 Synthesis
2,4-Dichloro-5-fluoroacetophenone

704-10-9
337 suppliers
$7.00/10g

Difloxacin

98106-17-3
86 suppliers
$259.00/1g

-

Yield:-

Steps:

Multi-step reaction with 6 steps
1: 80 percent / NaH / 1.5 h / 80 °C
2: Ac2O / 2 h / 130 °C
3: CH2Cl2 / 0.5 h / Ambient temperature
4: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C
5: aq. NaOH / tetrahydrofuran / 1.5 h / 80 °C
6: 21.3 g / various solvent(s) / 24 h / 110 °C

References:

Chu, Daniel T. W.;Fernandes, Prabhavathi B.;Claiborne, Akiyo K.;Pihuleac, Eva;Nordeen, Carl W.;et al. [Journal of Medicinal Chemistry,1985,vol. 28,# 11,p. 1558 - 1564]

FullText

86483-51-4 Synthesis
ETHYL 2,4-DICHLORO-5-FLUOROBENZOYLACETATE

86483-51-4
30 suppliers
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Difloxacin

98106-17-3
86 suppliers
$259.00/1g

References
3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester

98105-80-7
1 suppliers
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Difloxacin

98106-17-3
86 suppliers
$259.00/1g

References
Benzenepropanoic acid, 2,4-dichloro-5-fluoro-α-[[(4-fluorophenyl)amino]methylene]-β-oxo-, ethyl ester

98105-65-8
0 suppliers
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Difloxacin

98106-17-3
86 suppliers
$259.00/1g

References
(Z)-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-3-ETHOXY-ACRYLIC ACID ETHYL ESTER

86483-52-5
6 suppliers
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Difloxacin

98106-17-3
86 suppliers
$259.00/1g

References

Difloxacin Related Search:

4-Biphenylcarboxylic acid Norfloxacin Levofloxacin Ofloxacin 1-Methylpiperazine 3-Quinolinecarboxylic acid 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID Sarafloxacin