Difluoro-(4-isopropylphenyl)acetic acid synthesis
- Product Name:Difluoro-(4-isopropylphenyl)acetic acid
- CAS Number:1027514-26-6
- Molecular formula:C11H12F2O2
- Molecular Weight:214.21
1027514-27-7
9 suppliers
inquiry
1027514-26-6
8 suppliers
inquiry
Yield:1027514-26-6 240 mg
Reaction Conditions:
with potassium hydroxide in methanol;water at 60; for 2 h;
Steps:
38.2 (2) 2-(4-isopropylphenyl)-2,2-difluoroacetic acid
300 mg of ethyl 2-(4-isopropylphenyl)-2,2-difluoroacetate, adding 10 mL of methanol, 10 mL of water, 490 mg (8.7 mmol) of potassium hydroxide, stirring at 60 ° C for two hours, then rotary evaporation In addition to methanol, the aqueous layer was adjusted to pH 5 with hydrochloric acid, extracted with ethyl acetate (30 mL), dried over anhydrous sodium sulfate, and evaporated to remove solvent to give 2-(4-isopropylphenyl)-2,2-difluoroacetic acid the mixture was colorless liquid 240 mg. Used directly in the next step of the reaction.
References:
CN105085433,2019,B Location in patent:Paragraph 0377; 0381-0383
17356-09-1
85 suppliers
$15.00/1g
1027514-26-6
8 suppliers
inquiry