![](/CAS/GIF/381-73-7.gif)
Difluoroacetic acid synthesis
- Product Name:Difluoroacetic acid
- CAS Number:381-73-7
- Molecular formula:C2H2F2O2
- Molecular Weight:96.03
![Ethyl difluoroacetate](/CAS/GIF/454-31-9.gif)
454-31-9
451 suppliers
$10.00/10g
![Trifluoroacetic acid](/CAS/GIF/76-05-1.gif)
76-05-1
676 suppliers
$9.00/1g
![Difluoroacetic acid](/CAS/GIF/381-73-7.gif)
381-73-7
308 suppliers
$10.00/1g
![Ethyl trifluoroacetate](/CAS/GIF/383-63-1.gif)
383-63-1
474 suppliers
$10.00/25g
Yield:381-73-7 99%
Reaction Conditions:
at 85;Product distribution / selectivity;
Steps:
3
Ethyl difluoroacetate (60 g, 0.484 mol) is brought together with trifluoroacetic acid (56 g, 0.484 mol, 1 equivalent) in a glass reactor surmounted by a distillation column.The reaction medium is brought to the temperature of 85° C. at atmospheric pressure.Ethyl trifluoroacetate is distilled off while keeping the temperature of the distillation top at 63° C.A fraction of 69 g of ethyl trifluoroacetate is obtained.All of the ethyl difluoroacetate was consumed (DC=100%) and the difluoroacetic acid obtained at the distillation bottom has a purity of 99.5% by weight.The yield (RY) is greater than 99%.
References:
US2012/123159,2012,A1 Location in patent:Page/Page column 4
![Dichloroacetic acid](/CAS/GIF/79-43-6.gif)
79-43-6
293 suppliers
$22.00/25g
![Difluoroacetic acid](/CAS/GIF/381-73-7.gif)
381-73-7
308 suppliers
$10.00/1g
![2-CHLORO-1,1-DIFLUOROETHANE](/CAS/GIF/338-65-8.gif)
338-65-8
54 suppliers
inquiry
![Difluoroacetic acid](/CAS/GIF/381-73-7.gif)
381-73-7
308 suppliers
$10.00/1g
![CHLOROFLUOROACETIC ACID](/CAS/GIF/471-44-3.gif)
471-44-3
30 suppliers
$55.00/1g
![Difluoroacetic acid](/CAS/GIF/381-73-7.gif)
381-73-7
308 suppliers
$10.00/1g
![Tetrafluoroethylene](/CAS/GIF/116-14-3.gif)
116-14-3
46 suppliers
inquiry
![Difluoroacetic acid](/CAS/GIF/381-73-7.gif)
381-73-7
308 suppliers
$10.00/1g