DIFLUOROMETHYLDIMETHYLAMINE synthesis

Yield:683-81-8 75%

Reaction Conditions:

with hydrogen fluoride at 0; for 3 h;Inert atmosphere;

Steps:

2.1 Preparation of 1,1-difluoromethyl-N,N-dimethylamine

First, 10g (64mmol) of 1,1-dichloromethyl-N,N-dimethylamine is charged into a high-pressure vessel under protective gas, then cooled to 0°C, and then 5.6ml (320mmol) of HF is added. With stirring, the mixture was stirred at 0°C for 3 hours. After the reaction is completed, remove the excess HF and HCl that have formed under high vacuum, and distill out the product under absolute water conditions5.91g (48mmol), light yellow liquid, the yield is 75%

References:

CN111635321,2020,A Location in patent:Paragraph 0054-0056