DIISOBUTYLMALONIC ACID DIETHYL ESTER synthesis
- Product Name:DIISOBUTYLMALONIC ACID DIETHYL ESTER
- CAS Number:81749-14-6
- Molecular formula:C15H28O4
- Molecular Weight:272.38
10203-58-4
118 suppliers
$14.14/250mgs:
78-77-3
329 suppliers
$14.00/5g
81749-14-6
42 suppliers
$45.00/250mg
Yield:81749-14-6 412 g
Reaction Conditions:
Stage #1: (2-methylpropyl)-propanedioic acid, diethyl esterwith potassium-t-butoxide in tetrahydrofuran at 10 - 35;Inert atmosphere;
Stage #2: Isobutyl bromide in tetrahydrofuran at 10 - 35;Inert atmosphere;
Steps:
3.A The specific preparation steps of the present embodiment 4,4-bis (methoxymethyl)-2,6-dimethylheptane are as follows:
A, under the protection of inert gas at room temperature, take by weighing 1532g potassium tert-butoxide-tetrahydrofuran solution whose mass concentration is 13.05%, add in a 3L reaction flask, dropwise add 296g of compound a isobutyl diethyl malonate to the reaction In the bottle, keep the temperature at 10-35 , after the dropwise addition, stir for 2-4h; add 225g of compound b bromoisobutane into the reaction bottle, monitor the progress of the reaction by gas chromatography, and measure compound a isobutane. When the mass concentration of diethyl butylmalonate is less than 5%, the dropwise addition of compound b bromoisobutane is stopped to obtain reaction mixture 1; Distillation to obtain 412g of compound c;
References:
CN114276221,2022,A Location in patent:Paragraph 0058; 0062
4162-61-2
8 suppliers
inquiry
81749-14-6
42 suppliers
$45.00/250mg