Dimethyl 1H-pyrazole-3,5-dicarboxylate synthesis
- Product Name:Dimethyl 1H-pyrazole-3,5-dicarboxylate
- CAS Number:4077-76-3
- Molecular formula:C7H8N2O4
- Molecular Weight:184.15
67-56-1
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3112-31-0
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$18.00/1g
4077-76-3
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$6.00/100mg
Yield:4077-76-3 99%
Reaction Conditions:
with thionyl chloride at 0 - 80; for 4 h;Inert atmosphere;
Steps:
44 Preparation of Compound 119
In methanol (50 mL), 3,5-pyrazoldicarboxylic acid hydrate (5 g, 28.71 mmol) was dissolved, then thionyl chloride (6.28 mL, 86.15 mmol) was added thereto at 0°C under a nitrogen atmosphere, and then the mixture was heated to 80°C. The reaction solution was stirred for 4 hours and then concentrated to obtain Compound 119 (7.1 g, 99%). 1H-NMR (400 MHz, CDCl3) δ 7.34 (s, 1H), 3.96 (s, 6H) .
References:
EP3604311,2020,A1 Location in patent:Paragraph 0267; 0268
3112-31-0
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$18.00/1g
4077-76-3
115 suppliers
$6.00/100mg
67-51-6
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$6.00/25g
4077-76-3
115 suppliers
$6.00/100mg
123-54-6
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$10.00/25ml
4077-76-3
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$6.00/100mg
1729-67-5
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$15.00/1g
6832-16-2
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4077-76-3
115 suppliers
$6.00/100mg