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diMethyl 4-acetaMido-6-chloroisophthalate synthesis

3synthesis methods
201230-82-2 Synthesis
carbon monoxide

201230-82-2
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methyl 2-acetamido-4-chloro-5-iodobenzoate

335293-21-5
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diMethyl 4-acetaMido-6-chloroisophthalate

335293-22-6
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Yield:335293-22-6 74%

Reaction Conditions:

with bis-triphenylphosphine-palladium(II) chloride;triethylamine in N,N-dimethyl-formamide at 80; under 760.051 Torr; for 16 h;

References:

DeVita;Walsh;Young;Jiang;Ujjainwalla;Toupence;Parikh;Huang;Fair;Goulet;Wyvratt;Lo;Ren;Yudkovitz;Yang;Cheng;Cui;Mount;Rohrer;Schaeffer;Rhodes;Drisko;McGowan;MacIntyre;Vincent;Carlin;Cameron;Smith [Journal of Medicinal Chemistry,2001,vol. 44,# 6,p. 917 - 922]