ChemicalBook CAS DataBase List DIMETHYL PIMELATE

DIMETHYL PIMELATE synthesis

13synthesis methods

Product Name:DIMETHYL PIMELATE
CAS Number:1732-08-7
Molecular formula:C9H16O4
Molecular Weight:188.22

67-56-1 Synthesis

67-56-1
752 suppliers
$7.29/5ml-f

111-16-0
377 suppliers
$6.00/5g

1732-08-7
156 suppliers
$18.00/5g

Yield:1732-08-7 98.08%

Reaction Conditions:

with toluene-4-sulfonic acid for 7 h;Reflux;Large scale;

Steps:

3.1 Example 3
(1) Synthesis of dimethyl pimelate
In a 50-liter glass reactor with stirring and a thermometer, 5000 g of pimelic acid,25000ml of methanol, 200g of p-toluenesulfonic acid, start stirring, warming reflux 7h,Sampling raw material reaction is less than 0.5% is terminated;Then, the temperature was lowered to room temperature, and 300 g of sodium carbonate was added to neutralize p-toluenesulfonic acid. After filtration, methanol was removed from the filtrate to obtain 5911 g of crude dimethyl pimelate.The crude dimethyl pimelate was transferred to a 5000-ml single-mouth bottle for high-vacuum distillation. The oil bath temperature was 110°C.The degree of vacuum is 42 Pa, and the gas-phase collection temperature is 74° C., 5730 g of dimethyl pimelate can be obtained, with a content of 99.8% and a yield of 98.08%.

References:

Haimen Huaxiang Pharmaceutical Technology Co., Ltd.;Wu Tiansheng;Zhou Guang;Xu Benquan CN107417496, 2017, A Location in patent:Paragraph 0012; 0013; 0014

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111-16-0
377 suppliers
$6.00/5g

616-38-6 Synthesis