ChemicalBook CAS DataBase List Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide synthesis

6synthesis methods

Product Name:Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
CAS Number:75980-60-8
Molecular formula:C22H21O2P
Molecular Weight:348.37

487-68-3 Synthesis

487-68-3
334 suppliers
$6.00/5g

4559-70-0
308 suppliers
$8.00/5g

Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

75980-60-8
472 suppliers
$14.00/5g

Yield:75980-60-8 98%

Reaction Conditions:

Stage #1: mesytaldehyde;Diphenylphosphine oxide in dichloromethane; for 6 h;Green chemistry;
Stage #2: with ammonium metavanadate;dihydrogen peroxide at 8 - 20; for 5.5 h;Green chemistry;Reagent/catalyst;

Steps:

4 Example 4

37.61 g of 2,4,6-trimethylbenzaldehyde and 56.17 g of diphenylphosphine oxide were added to a three-necked flask with 450 mL of methylene chloride and stirred,Reaction for 6 hours,The three bottles into a low-temperature water bath to cool to 8 ~ 10 ,Followed by adding 0.2925g ammonium metavanadate (NH4VO3), 37mL H2O2 (30%),Low temperature reaction 0.5 hours,After placed at room temperature for mixing,Reaction for 5 hours.After the reaction was completed, 5% Na2S2O3 aqueous solution was added to the filtrate to neutralize the unreacted H2O2,extraction,The organic layer was collected,Washed three times with saturated salt water,Then add anhydrous sodium sulfate in addition to water,Then recrystallized,Suction filtration, drying,A pale yellow powdery solid was obtained,That is TPO products,Yield 98%.

References:

CN106905364,2017,A Location in patent:Paragraph 0030; 0031; 0032; 0033; 0034

707-74-4 Synthesis