Dopropidil synthesis
- Product Name:Dopropidil
- CAS Number:79700-61-1
- Molecular formula:C20H35NO2
- Molecular Weight:321.501
1310-73-2
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697-37-0
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56-37-1
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![1-[2-chloro-3-(2-methylpropoxy)propyl]pyrrolidine](/CAS/GIF/49571-02-0.gif)
49571-02-0
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79700-61-1
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Yield:-
Reaction Conditions:
in water;
Steps:
1 1-[1-(1-propynyl)-cyclohexyloxy]-2-(N-pyrrolidinyl)-3-iso-butoxypropane
EXAMPLE 1 1-[1-(1-propynyl)-cyclohexyloxy]-2-(N-pyrrolidinyl)-3-iso-butoxypropane 33 g of 1-pyrrolidinyl-2-chloro-3-isobutoxypropane were gradually introduced into a reactor containing 41.4 g of 1-propynyl cyclohexanol, 30 g of sodium-hydroxide previously dissolved in 30 ml of water and 3.1 g of benzyl triethylammonium chloride, while stirring well. When the addition had ended, the mixture was refluxed for 4 hours while the stirring was maintained. After cooling, the product formed was extracted with ether. The ether phase was filtered, decanted and washed with water, dried over sodium sulphate and then evaporated. After distillation of the residue 22 g of the product of the heading were obtained in the form of a clear yellow liquid. BP0,5 =130°-135° C., nD20 =1,483.
References:
US4430332,1984,A