(E)-3-(3,5-dimethoxyphenyl)acrylic acid synthesis
- Product Name:(E)-3-(3,5-dimethoxyphenyl)acrylic acid
- CAS Number:20767-04-8
- Molecular formula:C11H12O4
- Molecular Weight:208.21
Yield:20767-04-8 94.5%
Reaction Conditions:
with piperidine;pyridine at 100; for 2 h;
Steps:
1 Example 1 Preparation of 3-(3,5-dimethoxyphenyl)acrylic acid (1)
Dissolve 3,5-dimethoxybenzaldehyde (50.00g, 0.3mol) in pyridine 150.0mL, add malonic acid 38.0g (0.36mol) and piperidine (2.55g, 0.03mol) to warm to 100 2h.TCL showed that the reaction was completed. After the reaction solution was cooled to room temperature, it was poured into an appropriate amount of ice water, and hydrochloric acid was added dropwise to adjust the pH to 2.0.Stir at room temperature for 10 min, vacuum filter, wash the filter cake with water, and dry to obtain 59.21 g of white solid.The yield is 94.5%
References:
CN111072638,2020,A Location in patent:Paragraph 0078-0080
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