(E)-METHYL 2-CYANO-3-ETHOXYACRYLATE synthesis
1synthesis methods
- Product Name:(E)-METHYL 2-CYANO-3-ETHOXYACRYLATE
- CAS Number:71363-39-8
- Molecular formula:C7H9NO3
- Molecular Weight:155.15
Yield:71363-39-8 91%
Reaction Conditions:
with acetic acid for 6 h;Reflux;
Steps:
1 (E)-2 - cyano -3 - ethoxy-acrylic acid methyl ester (1) preparation of
A solution of methyl cyanoacetate (5.0 g, 50.5 mmol) and triethyl orthoformate (7.6 g, 51 mmol) was added to 20 mL of acetic acidAnhydride, reflux and stirring for 6h, cooling, ethyl acetate extraction, anhydrous MgS04 drying, filtration, spin dry solvent, pale yellow solid 7.1g, yield 91
References:
CN106946890,2017,A Location in patent:Paragraph 0082; 0083; 0084; 0085