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(E)-Methyl 3-(pyriMidin-5-yl)acrylate synthesis

1synthesis methods
4595-59-9 Synthesis
5-Bromopyrimidine

4595-59-9
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acrylic acid methyl ester

292638-85-8
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Yield:866621-24-1 89%

Reaction Conditions:

with palladium diacetate;N-ethyl-N,N-diisopropylamine;phosphorous acid trimethyl ester in N,N-dimethyl-formamide at 110; for 1 h;Inert atmosphere;Heck Reaction;

References:

Kwok, Thomas J.;Virgilio, Joseph A. [Organic Process Research and Development,2005,vol. 9,# 5,p. 694 - 696]