Erythromycin thiocyanate synthesis

Yield:7704-67-8 85.1%

Reaction Conditions:

Stage #1:erythromycin in acetone; pH=8.5 at 35;
Stage #2:sodium thiocyanide in acetoneConcentration;pH-value;Temperature;Solvent;

Steps:

1 Example 1
Example 1
Crude erythromycin (100 g) was added into acetone (600 mL), heated to 35° C. in a water bath and adjusted to pH 8.5.
Filtrate was obtained after filtration and the temperature of filtrate was kept at 35° C.
Then sodium thiocyanate was added into the filtrate and stirred to dissolve.
The molar ratio of sodium thiocyanate and erythromycin was 2:1.
The mixture was adjusted to pH 6.0 with acetic acid, cooled to 10° C. slowly and kept for 15 minutes.
Then precipitate was separated, washed with pure water (100 mL), crushed and dried to obtain erythromycin thiocyanate.
The amount of the main component dried erythromycin A was 85.1% (detected by HPLC).

References:

HEC PHARM CO., LTD;Xiong, Hui;Zhao, Keyi;Deng, Zhaozheng US2014/228555, 2014, A1 Location in patent:Paragraph 0042

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