![](/CAS/GIF/74-55-5.gif)
Ethambutol synthesis
- Product Name:Ethambutol
- CAS Number:74-55-5
- Molecular formula:C10H24N2O2
- Molecular Weight:204.31
![](https://www.chemicalbook.com/NewsImg/2021-01-25/20211251635836946.jpg)
An alternative method of synthesis consists of preparing (+) 2-aminobutanol (34.1.3) by reducing ethyl ester of L-2-aminobutyric acid hydrochloride with hydrogen using simultaneously Raney nickel and platinum oxide catalysts. This gives pure (+) 2-aminobutanol. Reacting this with 1,2-dichloroethane in the presence of sodium hydroxide gives the desired ethambutol (34.1.4).
![](https://www.chemicalbook.com/NewsImg/2021-01-25/20211251635238016.jpg)
The third way of synthesis is very interesting and resembles of the Ritter reaction, but which takes place in the presence of chlorine. This method consists of reacting 1-butene and acetonitrile in the presence of chlorine, which evidently results in the 1,4-addition of chlorine to the product of the Ritter reaction, forming an intermediate dichloride (33.1.5), which is hydrolyzed with water to make N-[1-(chloromethyl)-propyl]-acetamide (33.1.6). Heating this product with hydrochloric acid gives racemic (±) 2-aminobutanol, from which (+) 2-aminobutanol (34.1.3) is isolated as described above using L (+) tartaric acid. Reacting this with 1,2-dichloroethane in the presence of sodium hydroxide gives the desired ethambutol (34.1.4)
![](https://www.chemicalbook.com/NewsImg/2021-01-25/202112516354112149.jpg)
![(S)-(+)-2-Amino-1-butanol](/CAS/GIF/5856-62-2.gif)
5856-62-2
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$6.00/5g
![1,2-Dichloroethane](/CAS/GIF/107-06-2.gif)
107-06-2
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$14.00/25g
![Ethambutol](/CAS/GIF/74-55-5.gif)
74-55-5
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$22.00/100mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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74-55-5
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$22.00/100mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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![Ethambutol](/CAS/GIF/74-55-5.gif)
74-55-5
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$22.00/100mg
![N,N'-Bis[(S)-1-(tert-ButyldiMethylsilyloxyMethyl)propyl]ethanediaMide](/CAS/GIF/909567-52-8.gif)
909567-52-8
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$70.00/1mg
![Ethambutol](/CAS/GIF/74-55-5.gif)
74-55-5
123 suppliers
$22.00/100mg
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1000210-73-0
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![Ethambutol](/CAS/GIF/74-55-5.gif)
74-55-5
123 suppliers
$22.00/100mg