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54187-93-8

Ethane, 1-broMo-2-(Methylthio)- synthesis

3synthesis methods
-

Yield: 71%

Reaction Conditions:

with phosphorus tribromide in dichloromethane at 0 - 5; for 1 h;

Steps:

3.1 1. Preparation of compound 2 (structure shown below) in Example 3
Slowly add compound 1 (500mg, 5.4mmol) and PBr3 (4.3g, 16.3mmol) into 10mL DCM at zero temperature. After the addition, the mixed system was stirred at 0-5 degrees for 1 hour. Slowly add saturated sodium bicarbonate solution (pH=8) dropwise to filter off the solid, dry the filtrate, concentrate and evaporate to dryness (28 degrees) to obtain 0.59 g of yellow oil, yield: 71%.

References:

Shanghai Meiyue Bio-technology Co., Ltd.;Ye Guozhong;Li Shiqiang;Feng Yan;Wang Chaodong CN111362920, 2020, A Location in patent:Paragraph 0251; 0255-0258