Ethanol, 2-(4-quinolinyloxy)- synthesis

Yield:24220-96-0 65%

Reaction Conditions:

with potassium carbonate;copper dichloride at 20 - 130; for 16 h;Inert atmosphere;Sealed tube;

Steps:

GeneralExperimental Procedure for the Preparation ofcompounds (6a,c-k)

General procedure: In a sealed tube, N-heteroaryl bromide 5a,c-k (10 mmol), CuCl₂ (0.5 mmol) and K₂CO₃ (30 mmol) were charged and suspended in ethylene glycol (5 mL) and stirred at room temperature for 10 min. The blue colored suspension was refluxed at 130 °C for 16 h. The mixture was cooled to room temperature and diluted with H₂O (10 mL) and extracted with ethyl acetate (3 × 30 mL). The combined organic layers were washed with Brine (10 mL), dried over MgSO₄, filtered and concentrated in vacuo. Purification of the crude residue was performed by column chromatography on silica gel (except for compound 6g, which was crystallized using dioxane/cyclohexane).

References:

Hamdi, Abdelrahman;Mostafa, Amany S.;Watat, Cedric Nana;Laurent, Mathieu Y.;Ben Ayed, Kawther;Selim, Khalid B.;Dujardin, Gilles [Tetrahedron Letters,2016,vol. 57,# 51,p. 5825 - 5829] Location in patent:supporting information