ChemicalBook CAS DataBase List Ethanone, 1-(1-methyl-1H-pyrazol-3-yl)- (9CI)

Ethanone, 1-(1-methyl-1H-pyrazol-3-yl)- (9CI) synthesis

6synthesis methods

Product Name:Ethanone, 1-(1-methyl-1H-pyrazol-3-yl)- (9CI)
CAS Number:137890-04-1
Molecular formula:C6H8N2O
Molecular Weight:124.14

60031-47-2 Synthesis

60031-47-2
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Ethanone, 1-(1-methyl-1H-pyrazol-3-yl)- (9CI)

137890-04-1
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$155.00/50mg

Yield:137890-04-1 88%

Reaction Conditions:

with Dess-Martin periodane in dichloromethane at 20; for 2 h;

Steps:

3.3 Step 3) 1-(1-Methyl-1H-pyrazol-3-yl)acetaldehyde

Add 1-(1-methyl-1H-pyrazol-3-yl)ethanol (0.15 g, 1.2 mmol) to a 50 mL vialAnd dichloromethane (20.0 mL), Add Dess-Martin Oxidizer (1.0 g, 2.4 mmol) at room temperature.Stir at room temperature for 2 hours.Filtered, the filter cake was washed with dichloromethane, and the filtrate was dried.The residue was purified by neutral alumina column chromatography (petrole ether/ethyl acetate (v/v) = 6/1).A colorless oil (0.13 g, 88%).

References:

CN108690016,2018,A Location in patent:Paragraph 0420; 0429; 0430