ChemicalBook CAS DataBase List Ethanone,1-(2,3-diaminophenyl)-

Ethanone,1-(2,3-diaminophenyl)- synthesis

7synthesis methods

Product Name:Ethanone,1-(2,3-diaminophenyl)-
CAS Number:159724-49-9
Molecular formula:C8H10N2O
Molecular Weight:150.18

20864-49-7
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159724-49-9
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Yield:159724-49-9 72.28%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol; for 2 h;

Steps:

69.4

Step 4:1-(2,3-Diamino-phenyl)-ethanone; A slurry of 1-(2-amino-3-nitro-phenyl)-ethanone (0.2 g, 1.1 1 mmol) and 10% palladium on carbon (0.020 g) in methanol (10 ml.) was hydrogenated with a hydrogen balloon for 2 h. After completion of the reaction, the reaction mixture was filtered and evaporated under vacuum to obtain the title compound as off white solid (0.120 g, 72.28%)1 H N MR (300 MHz, DMSO-d6): δ (ppm) = 7.12(d, J=12Hz,1 H) 6.80(bs,2H) 6.70(d, J=12Hz,1 H) 6.44-6.36(m,1 H) 4.80(s,2H) 2.45(s,3H).

References:

WO2010/115736,2010,A2 Location in patent:Page/Page column 121-122

10202-87-6 Synthesis