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ChemicalBook CAS DataBase List (Ethanone, 1-[2,4,6-tris(methoxymethoxy)phenyl]- )
36804-11-2

(Ethanone, 1-[2,4,6-tris(methoxymethoxy)phenyl]- ) synthesis

5synthesis methods
-

Yield:36804-11-2 98.2%

Reaction Conditions:

with tetrabutylammonium bromide;sodium hydroxide in dichloromethane;lithium hydroxide monohydrate at 20; for 1 h;

Steps:

5.B

Step B: chloromethyl methyl ether (2.52 g, 31.3 mmol) was added dropwise to a solution containing compound 8 (4.0 g, 15.6 mmol), sodium hydroxide (1.84 g, 46 mmol).After a mixture of water (4 mL), tetrabutylammonium bromide (252 mg, 0.782 mmol) and dichloromethane (60 mL), the mixture was stirred at room temperature for 1 hour.Water (40 mL) was added, and extracted with dichloromethane (60 mL×2).Dry over anhydrous sodium sulfate. Evaporate the solvent under reduced pressure.2,4,6-Tris(methoxymethoxy)acetophenone (9) (4.6 g) was obtained. The yield was 98.2%.

References:

CN110183431,2019,A Location in patent:Paragraph 0135-0136; 0139