(Ethanone, 1-[2,4,6-tris(methoxymethoxy)phenyl]- ) synthesis

5synthesis methods

Product Name:(Ethanone, 1-[2,4,6-tris(methoxymethoxy)phenyl]- )
CAS Number:36804-11-2
Molecular formula:C14H20O7
Molecular Weight:300.3

65490-09-7 Synthesis

1-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)ethanone

65490-09-7
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107-30-2
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(Ethanone, 1-[2,4,6-tris(methoxymethoxy)phenyl]- )

36804-11-2
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Yield:36804-11-2 98.2%

Reaction Conditions:

with tetrabutylammonium bromide;sodium hydroxide in dichloromethane;lithium hydroxide monohydrate at 20; for 1 h;

Steps:

5.B

Step B: chloromethyl methyl ether (2.52 g, 31.3 mmol) was added dropwise to a solution containing compound 8 (4.0 g, 15.6 mmol), sodium hydroxide (1.84 g, 46 mmol).After a mixture of water (4 mL), tetrabutylammonium bromide (252 mg, 0.782 mmol) and dichloromethane (60 mL), the mixture was stirred at room temperature for 1 hour.Water (40 mL) was added, and extracted with dichloromethane (60 mL×2).Dry over anhydrous sodium sulfate. Evaporate the solvent under reduced pressure.2,4,6-Tris(methoxymethoxy)acetophenone (9) (4.6 g) was obtained. The yield was 98.2%.

References:

CN110183431,2019,A Location in patent:Paragraph 0135-0136; 0139

480-66-0 Synthesis