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Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)- synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: triethylamine / lithium hydroxide monohydrate; dichloromethane / 1 h / 20 °C / Cooling with ice
2.1: Cs2CO3; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 8 h / 80 °C
2.2: 1 h / 60 °C / pH 8 - 10

References:

CN113968861,2022,A