Ethanone, 1-[2-(methylamino)-5-pyrimidinyl]- (9CI) synthesis
- Product Name:Ethanone, 1-[2-(methylamino)-5-pyrimidinyl]- (9CI)
- CAS Number:265107-49-1
- Molecular formula:C7H9N3O
- Molecular Weight:151.17
593-51-1
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Yield:265107-49-1 89%
Reaction Conditions:
with triethylamine in tetrahydrofuran at 20;
Steps:
1 pyrirnidine 71
To a solution of 32 (117 mg. 0.76 nunol) in THF (30 niL) is added TEA (383 111g. 378 mrnoi) and methylamine hydrochloride (153 mg. 2.27 mmol). After stirring at room temperature overnight, the mixture is concentrated and purified by silica gel column chromatography (EA:PE == 1:4 to 1:1) to give 71 as a pale yellow solid (100 rng, 89% yield). (MS: [MH-Hi 152.1)
References:
WO2017/176812,2017,A1 Location in patent:Paragraph 0310