Ethanone, 1-(3-methoxy-2-pyridinyl)- (9CI) synthesis
- Product Name:Ethanone, 1-(3-methoxy-2-pyridinyl)- (9CI)
- CAS Number:379227-03-9
- Molecular formula:C8H9NO2
- Molecular Weight:151.16
917-64-6
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24059-89-0
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379227-03-9
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Yield:379227-03-9 79%
Reaction Conditions:
in tetrahydrofuran at 0; for 2 h;Inert atmosphere;
Steps:
1-(3-Methoxy-pyridin-2-yl)ethanone
3-Methoxy-2-cyanopyridine (0.88 g, 6.5 mmol) was dissolved in anhydrous tetrahydrofuran (20 mL) in a 3-neck flask under a nitrogen atmosphere.The reaction was cooled to 0 °C, and a solution of methylmagnesium iodide in tetrahydrofuran (3M, 4.3 ml, 12.8mmol) was added. The reaction was stirred at 0 °C for 2 hours and then quenched with 50 mL of water at 0 °C. The pH was adjusted to 7 with 2N HCl, and the resulting solution was extracted with ethyl acetate (3 x 50 mL)), the combined organic layers were dried over anhydrous sodium sulfate and concentrated on a rotary evaporator to provide the crude product. Silica gel chromatography (gradient of 0 - 100% ethyl acetate in hexane) provided the product as a colorless oil (0.79g, 79% yield). 1H-NMR (CDCl3) δ 8.42 (dd, J = 7.7 and 1.4Hz, 1H), 7.63 (dd, J = 7.6 and 1.4 Hz, 1H), 7.61 (dd, J = 7.7 and 7.6 Hz, 1H),3.82 (s, 3H), 2.14 (s, 3H), (ESI+): m/z (M+H)+= 152.
References:
Lounsbury, Nicole;Mateo, George;Jones, Brielle;Papaiahgari, Srinivas;Thimmulappa, Rajash K.;Teijaro, Christiana;Gordon, John;Korzekwa, Kenneth;Ye, Min;Allaway, Graham;Abou-Gharbia, Magid;Biswal, Shyam;Childers, Wayne [Bioorganic and Medicinal Chemistry,2015,vol. 23,# 17,p. 5352 - 5359] Location in patent:supporting information
81376-85-4
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379227-03-9
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38180-46-0
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379227-03-9
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$43.00/100mg