Ethanone, 1-imidazo[1,2-a]pyrimidin-3-yl- (9CI) synthesis
- Product Name:Ethanone, 1-imidazo[1,2-a]pyrimidin-3-yl- (9CI)
- CAS Number:453548-59-9
- Molecular formula:C8H7N3O
- Molecular Weight:161.16
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Yield:-
Reaction Conditions:
Stage #1: 2-aminopyrimidine;N,N-dimethyl-formamide dimethyl acetal in toluene at 100; for 48 h;
Stage #2: chloroacetone in toluene at 20; for 12 h;
Steps:
6-12
To prepare the imidazopyrimidine core, 2-aminopyrimidine 1 was treated first with N,N-dimethylformamide dimethyl acetal followed by 2-chloroacetone in toluene at 100 C for 48 h to give 1-(imidazo[1,2-a]pyrimidin-3-yl)ethan-1-one 2a.
References:
US10875861,2020,B1 Location in patent:Page/Page column 25; 26