ethyl 1-acetylcyclopropanecarboxylate synthesis

Yield:32933-03-2 78.1 g (65.1%)

Reaction Conditions:

with potassium carbonate in acetone;

Steps:

R.11.1 Ethyl 1-acetylcyclopropanecarboxylate

Referential Example 11-1 Ethyl 1-acetylcyclopropanecarboxylate Ethyl acetoacetate (100 g, 0.77 mol) was dissolved in acetone (500 ml). To the thus obtained solution was added dibromoethane (361 g, 1.92 mol) and potassium carbonate (266 g, 1.92 mol) and the mixture was heated under reflux for 4 days. After filtering off insoluble matter, the filtrate was distilled under reduced pressure (80° C./8 mmHg) to obtain 78.1 g (65.1%) of the title compound as a colorless oily substance. ¹ H-NMR (400 MHz, CDCl₃) δ: 1.29 (3H, t, J=7.33 Hz), 1.47 (4H, s), 2.47 (3H, s), 4.21 (2H, q, J=7.33 Hz).

References:

US6121285,2000,A