ChemicalBook CAS DataBase List ETHYL 1-BENZOFURAN-3-YLACETATE

ETHYL 1-BENZOFURAN-3-YLACETATE synthesis

11synthesis methods

Product Name:ETHYL 1-BENZOFURAN-3-YLACETATE
CAS Number:82156-58-9
Molecular formula:C12H12O3
Molecular Weight:204.22

7169-34-8
214 suppliers
$13.00/1g

Ethyl (triphenylphosphoranylidene)acetate

1099-45-2
361 suppliers
$6.00/5g

82156-58-9
48 suppliers
$208.94/250mg

Yield: 98%

Reaction Conditions:

in toluene for 48 h;Heating / reflux;

Steps:

39.4
Step 4: A mixture of benzofuran-3(2H)-one (1.34 g, 10 mmol) and (carboxymethylene)triphenylphosphorane (5.22 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. At the end, the reaction mixture was concentrated and loaded over a silica-gel column. The column was eluted with hexane (500 ml) and then with 25% ethyl acetate. The product, ethyl(-1-benzofuran-3-yl)acetate was obtained as a white oil. Yield: 2.0 g (98%); (M+H): 205.

References:

Venkatesan, Aranapakam Mudumbai;Santos, Osvaldo Dos;Asselin, Magda;Grosu, George Theodore;Evrard, Deborah A.;Mewshaw, Richard Eric;Meagher, Kristin US2009/54454, 2009, A1 Location in patent:Page/Page column 21