Ethyl 1-Benzylpyrazole-3-carboxylate synthesis
- Product Name:Ethyl 1-Benzylpyrazole-3-carboxylate
- CAS Number:174907-58-5
- Molecular formula:C13H14N2O2
- Molecular Weight:230.26
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Yield:174907-58-5 66%
Reaction Conditions:
with bromine;potassium carbonate in acetonitrile at 20; for 8 h;
Steps:
1-Benzyl-1H-pyrazole-3-carboxylic acid ethyl ester (QY-9-15):
In a 250ml round-bottomed flask, 3-ethoxycarbonylpyrazole (6.0g, 42.8mmol) was stirred and mixed in 90ml of acetonitrile, potassium carbonate (17.8g, 128.4mmol) was added to the reaction solution, and bromine was added under vigorous stirring at room temperature. Benzyl chloride (8.8 g, 51.4 mmol) was added dropwise to the reaction system, the reaction was monitored by LC-MS, and the reaction was stopped after stirring for 8 h. Suction filtration through diatomaceous earth to remove inorganic salts, spin drying to remove organic solvents,Silica gel column chromatography separation and purification (petroleum ether: ethyl acetate = 0-50%) to obtain 6.54 g of white solid, yield 66%.
References:
WO2022/57787,2022,A1 Location in patent:Page/Page column 28
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174907-58-5
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5932-27-4
215 suppliers
$16.18/1G
100-44-7
649 suppliers
$13.50/250G
174907-58-5
10 suppliers
inquiry