ethyl 2-(2,4-difluorophenyl)acetate synthesis

1synthesis methods

Product Name:ethyl 2-(2,4-difluorophenyl)acetate
CAS Number:129409-54-7
Molecular formula:C10H10F2O2
Molecular Weight:200.18

64-17-5 Synthesis

64-17-5
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$10.00/50g

81228-09-3 Synthesis

81228-09-3
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$12.00/2g

129409-54-7
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$85.00/1G

Yield:129409-54-7 95.5%

Reaction Conditions:

with sulfuric acid at 20; for 48 h;

Steps:

19

Concentrated sulfuric acid (3 mL) was added slowly to a stirred solution of 2,4 di- fluorophenylacetic acid a (10.0 g, 58.1 mmol) in EtOH (100 mL), stirred at RT for 2 d. It was concentrated, diluted with EtOAc (200 mL), washed with 10% K₂CO₃ until the washes EPO were basic, dried (MgSO₄), and concentrated in vacuo to afford 11.1 g (95.5%) of difluoro ester b as a white solid.

References:

WO2006/69063,2006,A1 Location in patent:Page/Page column 87-88