ethyl 2-(2,5-dichlorophenoxy)acetate synthesis
- Product Name:ethyl 2-(2,5-dichlorophenoxy)acetate
- CAS Number:61763-88-0
- Molecular formula:C10H10Cl2O3
- Molecular Weight:249.09
583-78-8
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$15.00/250mg
105-36-2
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$5.00/5G
61763-88-0
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$474.00/1g
Yield:-
Reaction Conditions:
with potassium carbonate in acetone;Reflux;Williamson Ether Synthesis;
Steps:
2.7.1. General procedure for the preparation of compound b
General procedure: To a solution of a selected phenol (a, 5 mmol) in dry acetone(25 mL) was added an equivalent of anhydrous K2CO3, which was heated to reflux (or in dry DMSO at room temperature). Then, 4.5 mmol of ethyl bromoacetate (or ethyl 3-bromopropionate) in dry acetone or DMSO (5 mL) was added dropwise over 30 min. The reaction mixture was stirred for 3-8 h (monitored by TLC), and was poured into distilled water (20 mL). The mixture was extracted with EtOAc (3×50 mL),dried over MgSO4, filtered, and concentrated in vacuo. The crude product was purified by flash silica chromatography to afford b.
References:
Ni, Wei-Wei;Liu, Qi;Ren, Shen-Zhen;Li, Wei-Yi;Yi, Li-Li;Jing, Heng;Sheng, Li-Xin;Wan, Qin;Zhong, Ping-Fu;Fang, Hai-Lian;Ouyang, Hui;Xiao, Zhu-Ping;Zhu, Hai-Liang [Bioorganic and Medicinal Chemistry,2018,vol. 26,# 14,p. 4145 - 4152] Location in patent:supporting information
582-54-7
23 suppliers
$57.50/250mg
61763-88-0
13 suppliers
$474.00/1g