Ethyl 2-(2-bromophenyl)-2-oxoacetate synthesis

5synthesis methods

Product Name:Ethyl 2-(2-bromophenyl)-2-oxoacetate
CAS Number:62123-82-4
Molecular formula:C10H9BrO3
Molecular Weight:257.08

64-17-5 Synthesis

64-17-5
719 suppliers
$10.00/50g

26767-16-8
33 suppliers
$65.00/250mg

62123-82-4
17 suppliers
$265.82/1g

Yield:62123-82-4 80%

Reaction Conditions:

with dichloro sulfoxide at 80; for 12 h;

Steps:

I-15.4 Synthesis of ethyl 2-(2-bromophenyl)-2-oxoacetate

Into a 250-mL 3-necked round-bottom flask, was placed a solution of 2-(2-bromophenyi)-2- oxoacetic acid (10 g, 43.66 mmol, 1.00 equiv) in ethanol (80 mL). This was followed by the addition of thionyl chloride (20 mL) dropwise with stirring. The resulting solution was stirred for 12 h at80 °C in an oil bath. The resulting mixture was concentrated under vacuum. The residue was dissolved in 100 mL of ethyl acetate. The resulting mixture was washed with 2x50 mL of water. The mixture was dried over anhydrous sodium sulfate. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 :5). This resulted in 9 g (80%) of ethyl 2-(2-bromophenyl)-2- oxoacetate as yellow oil. MS (ESI) m/z 258 ([M + H]⁺)

References:

WO2014/143960,2014,A1 Location in patent:Page/Page column 33-34

50671-05-1 Synthesis