Ethyl 2-(2-ethyl-1H-imidazol-1-yl)acetate synthesis

Yield:934172-26-6 30%

Reaction Conditions:

with potassium carbonate in acetone; for 12 h;Heating / reflux;

Steps:

129.a

a) (2-Ethyl-imidazol-1-yl)-acetic acid ethyl ester 2-Ethyl-imidazole (10.0 g, 104 mmol) was dissolved in acetone (80 mL) and then ethyl bromoacetate (17.4 g, 104 mmol) and potassium carbonate (2.6 g, 18.7 mmol) was added and the resulting mixture was heated under reflux for 12 h. After filtration and evaporation the residue was extracted with water and dichloromethane. The organic phase was dried over sodium sulfate and evaporated to afford the title compound as a light yellow solid (5.76 g, 30%). MS: m/e=183.1 [M+H]⁺.

References:

US2007/82890,2007,A1 Location in patent:Page/Page column 37