Ethyl 2-(3-amino-4-fluorophenyl)acetate synthesis
- Product Name:Ethyl 2-(3-amino-4-fluorophenyl)acetate
- CAS Number:858972-17-5
- Molecular formula:C10H12FNO2
- Molecular Weight:197.21
858972-16-4
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858972-17-5
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Yield:858972-17-5 177 g
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen at 40; for 16 h;
Steps:
1.2; 2.2; 8.2 2) Reduction reaction
The crude product obtained in step 1) was dissolved in 1.2 L of ethanol, 1 g of 10% palladium-carbon was added, and hydrogen was replaced three times, and hydrogenated at 40 ° C under normal pressure for 16 hours. The nitrogen was replaced and the palladium on carbon was filtered off. Desolvation under reduced pressure gave ethyl 3-amino-4-fluorophenylacetate, 177 g, 90% yield in two steps, and 98.7% purity by HPLC.
References:
CN110845337,2020,A Location in patent:Paragraph 0036; 0039; 0042; 0045; 0074-0077
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