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Ethyl 2-(4-broMophenyl)acrylate synthesis

6synthesis methods
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Yield:331779-03-4 96%

Reaction Conditions:

Stage #1: 2-bromo-acrylic acid ethyl esterwith naphthalene;tetraethylammonium perchlorate;zinc in N,N-dimethyl-formamide at -20; for 1 h;
Stage #2: 1,4-bromoiodobenzene;dichlorobis(tri-O-tolylphosphine)palladium in N,N-dimethyl-formamide at 70; for 3 h;

References:

Jalil;Kurono;Tokuda [Synlett,2001,# 12,p. 1944 - 1946]