![](/CAS/GIF/3943-91-7.gif)
ETHYL 2 5-DIHYDROXYBENZOATE 97 synthesis
- Product Name:ETHYL 2 5-DIHYDROXYBENZOATE 97
- CAS Number:3943-91-7
- Molecular formula:C9H10O4
- Molecular Weight:182.17
![2,5-Dihydroxybenzoic acid](/CAS/GIF/490-79-9.gif)
490-79-9
489 suppliers
$5.00/100mg
![Boron trifluoride diethyl etherate](/CAS/GIF/109-63-7.gif)
109-63-7
380 suppliers
$10.60/1gm:
![ETHYL 2 5-DIHYDROXYBENZOATE 97](/CAS/GIF/3943-91-7.gif)
3943-91-7
36 suppliers
$28.00/500mg
Yield:3943-91-7 99%
Reaction Conditions:
at 120; for 4 h;
Steps:
Representative procedure (compound 1)
General procedure: In a 50 mL two-necked round-bottomed flask equipped with a magnetic stirring bar, a reflux condenser and a calcium chloride drying tube was placed nicotinic acid (1 g, 8.1 mmol) suspended in boron trifluoride etherate (10 mL). The reaction mixture was stirred and heated to 120 °C overnight during which the creamy reaction mixture changed into a brownish solution. Thin layer chromatography (hexane/ethyl acetate 3:1) revealed complete reaction. The cooled reaction mixture was diluted with water (25 mL) and extracted with ethyl acetate (3 x 10 mL). The combined organic extract was washed to the end of effervescence with a saturated solution of NaHCO3. The organic phase was dried over anhydrous Na2SO4 and concentrated in vacuo giving a crude yield of 1.11 g (92%).
References:
Jumbam, Ndze D.;Maganga, Yamkela;Masamba, Wayiza;Mbunye, Nomthandazo I.;Mgoqi, Esethu;Mtwa, Sphumusa [Bulletin of the Chemical Society of Ethiopia,2018,vol. 32,# 2,p. 387 - 392]
![Ethanol](/CAS/GIF/64-17-5.gif)
64-17-5
707 suppliers
$10.00/50g
![2,5-Dihydroxybenzoic acid](/CAS/GIF/490-79-9.gif)
490-79-9
489 suppliers
$5.00/100mg
![ETHYL 2 5-DIHYDROXYBENZOATE 97](/CAS/GIF/3943-91-7.gif)
3943-91-7
36 suppliers
$28.00/500mg
![Furan, 2,5-bis[(trimethylsilyl)oxy]-](/CAS2/GIF/77220-06-5.gif)
77220-06-5
1 suppliers
inquiry
![Ethyl acrylate](/CAS/GIF/140-88-5.gif)
140-88-5
515 suppliers
$12.00/100ml
![ETHYL 2 5-DIHYDROXYBENZOATE 97](/CAS/GIF/3943-91-7.gif)
3943-91-7
36 suppliers
$28.00/500mg
![Diethyl sulfate](/CAS/GIF/64-67-5.gif)
64-67-5
351 suppliers
$14.00/5g
![2,5-Dihydroxybenzoic acid](/CAS/GIF/490-79-9.gif)
490-79-9
489 suppliers
$5.00/100mg
![ETHYL 2 5-DIHYDROXYBENZOATE 97](/CAS/GIF/3943-91-7.gif)
3943-91-7
36 suppliers
$28.00/500mg
![5-Aminosalicylic acid](/CAS/GIF/89-57-6.gif)
89-57-6
761 suppliers
$5.00/50mg
![ETHYL 2 5-DIHYDROXYBENZOATE 97](/CAS/GIF/3943-91-7.gif)
3943-91-7
36 suppliers
$28.00/500mg