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ethyl 2-chloro-4-MethoxypyriMidine-5-carboxylate synthesis

8synthesis methods
3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-7-CARBALDEHYDE

200195-19-3
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ethyl 2-chloro-4-MethoxypyriMidine-5-carboxylate

253687-16-0
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Yield:253687-16-0 76%

Reaction Conditions:

with sodium tetrahydroborate in methanol at 0; for 1 h;Reduction;

References:

Belliotti, Thomas R.;Wustrow, David J.;Brink, Wouter A.;Zoski, Kim T.;Shih, Yu-Hsin;Whetzel, Steven Z.;Georgic, Lynn M.;Corbin, Ann E.;Akunne, Hyacinth C.;Heffner, Thomas G.;Pugsley, Thomas A.;Wise, Lawrence D. [Journal of Medicinal Chemistry,1999,vol. 42,# 25,p. 5181 - 5187]